Tom Hanks - voice of Toy Story cowboy Woody - has admitted the film reduced him to tears during a poignant montage featuring cowgirl Jessie.
"I was in tears, and we were looking at each other going, 'That's some powerful stuff' - to be reduced to that and to a level of emotion like that on a cartoon about talking toys and their adventures, it's profound, there's no other word for it," he says.
Tim Allen, the voice of Buzz Lightyear adds: "It's embarrassing, Tom, is what it is. Grown men weeping."
The comical duo have slipped back into their animated alter-egos for Toy Story 3 and are still surprised that the Disney films continue to pack such an emotional punch.
"It is a profoundly moving and special experience," said Tom.
"Look, we make a lot of things, and we see them for the first time - by and large it kind of works; maybe it works, maybe it doesn't, but the three Toy Story movies we've seen, every time I've come out of there I've just slapped my head and said, 'I can't believe I'm a part of this'."