Cheryl Cole has pulled out of a charity appearance for Children In Need, suffering from a sore throat.
The singer had been due to perform a duet with Take That star Gary Barlow at the Children In Need Rocks concert which he has organised on Thursday.
But Cheryl - who suffered ill health last year when she was struck down with malaria - has now been forced to cancel.
A spokesman for the singer said: "Cheryl Cole has sadly had to pull out of a performance at CIN Rocks this week as she is suffering from pharyngitis."
On Tuesday Gary warned that the collaboration in Manchester was hanging in the balance because of her health.
It would have been Cheryl's first performance for months in the UK, in a year which saw her axed as a judge from the US version of X Factor.
Organisers had been informed she is having problems with her throat. Gary said yesterday he would have to think of a contingency plan just in case.
"I don't know what we're going to do. I might just have to get on the piano and do a bit of Roll Out The Barrel," he joked.