Lady Gaga's latest album is on course to outsell the rest of the top 30 put together with around 250,000 copies sold in the first week.
Born this Way looks certain to take the top spot according to figures from the Official Charts Company.
It will push Adele's 21 - which has held the number one spot for 16 weeks out of 20 this year - down into second place.
The flamboyant star, whose real name is Stefani Germanotta, also looks likely to have three singles in the Top 20 chart this Sunday.
HMV's Gennaro Castaldo said sales reflected her position as "undoubtedly the biggest pop star on the planet right now".
The weird and wonderful wardrobe of Lady Gaga