The band have already called off a tour date in Atlanta this week, but Duran Duran are now cancelling a string of tour dates due to keyboardist Nick Rhodes' illness.
The foursome, known for their hits such as Girls on Film and Rio, have cancelled their final four US tour dates and two shows in Canada.
Nick is suspected to be suffering from exhaustion or a possible viral infection.
A message on Duran Duran's website said: "Nick held out all week, hoping that he would be well enough to perform again for these final few shows, but unfortunately the medical advice he has been given today requires him to continue to rest."
The band have been touring for the past two years to promote their latest album, All You Need Is Now.