The actress, sparkling in a backless midnight black dress, made her first televised appearance since news of her husband's infidelities broke.
And she was the talk of the evening after jokingly planting a kiss on Scarlett Johansson, before telling the audience: "Now that we have done that, can we please go back to normal?"
The last time Sandra was seen on TV was when she picked up an Oscar, with Jesse James at her side. This time around, as she collected the MTV generation award, she was alone – having filed for divorce and deciding to bring up her adopted son Louis on her own.
Sandra's smooch was just one of the highlights of the ceremony.
A particular hit with the audience was Tom Cruise's collaboration with Jennifer Lopez. The Hollywood heavyweight reprised his role as Les Grossman – the foul-mouthed Tinseltown producer from Tropic Thunder - and took part in a show-stopping hip-hop routine.
There were more great musical performances, from Katy Perry – who donned a blue wig and Wonder Woman-inspired costume to sing California Gurls - and Christina Aguilera. The platinum blonde thrilled with a high energy performance of her new track Bionic.
And one for the Twi-hards – the chance to get a closer look at Robert Pattinson's newly-cropped hair as he joined girlfriend Kristen Stewart and Taylor Lautner on stage.