But while those endorsements have featured glamorous shots of the American beauty, her latest billboard venture is a different matter altogether.
For her latest campaign, Jennifer searched through her own childhood photo albums to find a portrait of herself as a little girl.
This week the mum-of-two and her husband Marc Anthony were on hand in New York to see the snap unveiled in Times Square as part of the Boys and Girls Clubs Youth Advocacy Campaign – the BGCA.
J Lo giggled with delight as the image of her wearing plaited pigtails and a checked school pinafore was revealed alongside the words: "Be Extraordinary".
The singer is an alumnus of the Kips Bay Boys and Girls Club in the Bronx, and credits the 'K Company' for teaching her to sing and dance through its famous performing arts program.
"I wanted to be there every day," Jennifer said at the launch. "They taught me how to be disciplined and be perseverant and to believe in my God-given talents.
"They encouraged me to be great in whatever I decided to do. And they taught me that I could do whatever I wanted."
The multi-talented performer has such fond memories of her time in the Boys and Girls Club in the Bronx, she is considering bringing along her two-year-old twins, Max and Emme, to take part.
"I think it's really, really important to work hard…Being able to accomplish something with dedication and hard work and commitment. That is something I would like them to learn as well," she told People.