Gwyneth spoke about her father, director Bruce Paltrow, who lost his life to cancer in 2002, saying: "It's been almost a decade now and I'm sort of more used to the fact that he's not here in physical body.
"I definitely feel his presence, and I think he would be really happy that I'm here tonight doing this and trying to spare other people from what he went through."
Gwyneth Paltrow, who was an executive producer for the gala, spoke about the loss of her father, Bruce, to cancer
There was live music from Alicia Keys, Tim McGraw and Taylor Swift. Taylor composed a song specifically for the event which she wrote after reading a blog about a three-year-old cancer sufferer named Ronan, written by his mother, Maya Thompson. British band Coldplay also performed their song Paradise
Actors Michael Douglas and Matt Damon showing their support. Michael, who had throat cancer said: "Cancer didn't bring me to my knees, it brought me to my feet. I stand tonight because I want to be part of this effort to find an end to cancer. This is possible."
Robert Pattinson, Julia Roberts, Jessica Biel and her fiancé Justin Timberlake all took to the stage during the gala. Julia commented that the entertainment community must go after the disease "with everything we've got."
Sofia Vegara and Stacey Kiebler helped man the phones as donations poured in
George Clooney's girlfriend Stacey Kiebler, Gwyneth Paltrow, Alicia Keys and Sofia Vegara all sported Stand up to Cancer shirts