The Two and a Half Men star, 36, recently got engaged to his girlfriend Mila Kunis and looks ready to settle down.
"Being a single guy can be a lot of fun… when you're financially independent [and] can do whatever you want, whenever you want," Ashton told Men's Fitness.
"For every girl you have a good time with for one night, if you want to stay single, that's the same girl that you have to not call back. After a while, being the one-night stand guy is also just a little gross."
Mila Kunis and Ashton Kutcher
Ashton was previously married to Demi Moore, 51, but the pair announced their separation after six years. The Iowa-born actor was accused of cheating on Demi in 2011, when he reportedly had a fling with San Diego college student Sara Leal.
At the time of the alleged tryst, which happened on Ashton and Demi's sixth wedding anniversary at the Hard Rock Hotel in San Diego, the actor claimed that he and his then-wife had already separated. Shortly after, Ashton moved out of their family home.
"As a woman, a mother and a wife, there are certain values and vows that I hold sacred, and it is in this spirit that I have chosen to move forward with my life," Demi said at the time.
Ashton and Demi Moore
Private couple Ashton and Mila have largely kept their engagement under wraps, as the actor's divorce from Demi was finalised in November 2013.
Reports suggest that Ashton and Mila have been engaged since last summer, when the heartthrob popped the question at Mila's 30th birthday. The Ukraine-born beauty sparked rumours when she was pictured wearing a diamond sparkler on her ring finger last month.
Ashton and Mila, who have been dating for two years, first met on the set of popular sitcom That 70's Show where they played on-screen couple Jackie and Kelso for eight years.
CBS announced that the Black Swan actress is set to appear on Two and a Half Men alongside her fiancé, and will play Vivian — a young, free spirited traveller, who turns up on Ashton's character, Walden's, doorstep and plays with his heart strings.