James and Seth — who have previously done a parody of the Hollywood couple's music video Bound 2 — took it upon themselves to act as Kim and Kanye stand-ins for a second time.
In the spoof photo, James reprised the role of Kanye and stood behind his "fiancée" Seth, who acted as queen of reality TV Kim.
James and Seth step in for Kanye and Kim
James was pictured tilting his head and smiling directly at the camera — a more laid-back approach to Kanye's serious gaze on the original cover.
Seth, meanwhile, played the perfect bride, beaming away and nuzzling into James' face.
Click here to see the original magazine cover
The amusing duo posted their photo-shopped version of the magazine cover on Twitter and Instagram, with the 127 Hours actor writing, "Seth! Love you, dog!"
"It had to be done," replied Seth on his Twitter page.
James and Seth parody Bound 2
This was the second time the close friends had starred as Kim and Kanye, and while their parody video of Bound 2 was greatly appreciated by the couple with Kim tweeting "You nailed it!!! Sooo funny!", the engaged lovebirds have yet to comment on the new photo.
Bound 2 photos: Kim and Kanye vs. James and Seth
Rumours had been swirling that Kim and Kanye would grace the cover of American Vogue for months, and on Friday, the much-anticipated spread was revealed.
Seth is spot-on as Kim
Kim was quick to take to Twitter to share her excitement, writing, "This is such a dream come true!! Thank you @VogueMagazine for this cover! O M GGGGG!!! I can't even breath!"
"#TRILL Thank you @voguemagazine," posted Kanye, seemingly showing how grateful he was to the "fashion bible" for "staying true," according to the Urban Dictionary.
The publication released a video to accompany the high-profile fashion shoot, in which the couple's nine-month-old daughter North West appears. The toddler may well be part of the full inside spread.