Speaking on The Howard Stern Show on Wednesday, 33-year-old Nick said Mariah "doesn’t even know who Kim Kardashian is" because "she doesn’t pay attention to that."
Nick's comments about Mariah come a week after he claimed to have been involved with Kim in an interview published by New York radio show, Power 106.
Nick, who has since said that Mariah was annoyed Nick talked about his personal life, also said that his marriage is better than any other relationship he's had.
Nick also said that he and Mariah, who married in 2008, don't let the fact they share their bed with their three-year-old twins Monroe and Moroccan interfere with their relationship.
"We have a big house, Howard!" He told the presenter. "We've got special rooms."
Nick and Mariah have been married since 2008
TV personality Nick reportedly landed in hot water with Mariah after naming a list of stars he had been intimate with.
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While being quizzed about how many celebrities he had been with, Nick said "That's a lot! This is LA!" Before naming Mariah, his ex Christina Milian, his former fiancée Selita Banks, singer Nicole Scherzinger and Kim Kardashian.
Nick dated Kim in 2006
"The world knew these [names]," Nick said afterwards. "These weren’t like names that, you know, I pulled out of a hat – these are people you’ve seen me on red carpets with, engaged, in love and all of that stuff, so wasn’t like it was new information."
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"You know sometimes, as my wife says, sometimes I should just keep my big mouth shut."