According to some reports, the 21-year-old was also following on-off boyfriend Justin Bieber, but has now bid farewell to him on the social networking site.
Her sudden and inexplicable friends cleanse seems to have come at an emotional time for Selena.
At the start of the week she posted a moody selfie, showing her wearing heavy black eyeliner and a sombre expression. She quoted Amy Winehouse in the caption, writing, "I go back to, black."
The following day, on Tuesday, she posted a shot of a review of Mary J. Blige's 2007 album Growing Pains, which included lyrics from the track Work in Progress.
Last week, Selena was spotted at Coachella with Justin, leading many to believe that the couple were back together.
Justin, 20, surprised the crowd when he came on stage to support his friend, Chance The Rapper — but it was the presence of Selena watching from the side that raised more eyebrows.
"Right after his performance, Bieber walked off stage and watched the rest of Chance's set with Selena Gomez," a source told People. "They were there for around 15 minutes until Bieber touched Gomez on her mid back as if to say, 'Let's go,' and the two left together."
Another onlooker, Ryan Marker, posted on Twitter, "Just saw @justinbieber and @selenagomez holding hands backstage at coachella… looks like they are back together."