In an interview with BBC Radio Five Live, the Oscar winner seemed to confirm reports that she will playing the Egyptian queen on the big screen.
Angelina Jolie has hinted she will retire from acting after appearing as Cleopatra
"We've been working on it," Angelina, 38, said. "There's been lots of different ideas of directors and lots of different discussions. The script has been written by Eric Roth, who is a dear friend and a brilliant writer."
Brad Pitt's leading lady added, "She's complicated. It's complicated to get this one right. I think we're getting there. It's getting close.
"I imagine the preparation for it is going to be big. It's one of those that you think maybe that's the one you put everything into and that's where you end it, that's where you finish – in a great way. What could you do beyond that one?"
Angelina Jolie and Brad Pitt
It's not the first time that Angelina has hinted her acting career will be taking a back seat in the near future.
At a press conference for Maleficent last month, she told journalists she wanted to focus more on her directing and her humanitarian work as a special envoy for the United Nations High Commissioner for Refugees.
"I've had a wonderful career and I'm very happy to have had all the opportunities to tell stories and work for as long as I have," she said.
Angelina Jolie has said she wants to focus more on directing and her humanitarian work
"I'm sure there will be more films but I am happy I am able to be selective and have fun with characters like this. But I would like to focus on writing and directing, and above all I would like to focus more on my work with the UN."