According to People, the split resulted from the strain of the couple living far apart.
"It was the distance," a source told the magazine. "She lives in New York and he resides in Indiana. It was the long distance that ultimately was the cause."
Meg Ryan and John Mellencamp in June 2013
Closer Weekly also claims that musician John struggled with the lack of privacy that comes with dating a Hollywood star and wants to opt out of the limelight.
"They split a couple of weeks ago," reported the publication. "I don't think he loved all the attention he got just from dating an actress. I bet he'll stay away from dating another famous person for a while."
Meg, 52, and John, 62, had formed a close family unit during their time together and were recently spotted out and about in New York with the You've Got Mail star's nine-year-old daughter Daisy.
The couple formed a close family unit and were often seen together in New York
Pink Houses hitmakter John was previously married to eighties supermodel Elaine Irwin. The couple ended their marriage in 2011 after 19 years together.
Meg Ryan joins stars at L'Wren Scott's memorial service
Meg was married to actor Dennis Quaid from 1991 to 2001. The couple have a 22-year-old son named Jack together and following their split Meg adopted Daisy from China.
The Connecticut-born star then briefly dated Russell Crowe in 2001 after starring alongside him in thriller Proof Of Life.