As part of his role as a Unicef ambassador, the former England footballer is due to star in a video about ways to control the epidemic.
In the video, which will be broadcast across West Africa, the 39-year-old father-of-four will stress how important cleanliness and hygiene are to preventing the spread of the virus.
David, pictured in 2009, visiting Cape Town with Unicef
"To have David Beckham involved in this campaign is massive for us and we are so grateful to him," Sierra Leone Football Association president Isha Johansen told the Sun. "In Sierra Leone football is a religion.
"All men, women and children follow a player or a team from the Premier League but David Beckham is the favourite.
"Our country and the whole of West Africa is facing a terrible plight," she added. "And the numbers who are dying are incredible."