The two sisters told E! News, "There are incredible teens on this list and we are so proud to be in their company."
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Kendall Jenner and Kylie Jenner feel "honoured" to have been included on Time's Influential Teens list
There are a number of remarkable youngsters named on the prestigious list, including Malala Yousafzai, who just became the youngest person to receive the Nobel Peace Prize in honour of her activism for women's education.
Sasha and Malia Obama, the daughters of President Barack Obama and his wife Michelle, also feature.
Kylie and Kendall's inclusion on the list has divided opinion, with some disagreeing with Time's decision.
Malala Yousafzai, 17, recently became the youngest ever Nobel Peace Prize recipient
But others have come out in support of the siblings, arguing that, for better or worse, their spot is deserved.
"They are influential to teens," Wendy Williams said on her talk show on Tuesday. "Either teen girls want to look like them… or dress like them."
She added, "They follow them on Instagram. They should be in this list, that's all!"