But what the movie star clearly hasn't lost is a knack for picking gorgeous girlfriends.
Elisabetta Canalis, the beautiful Italian presenter, he's been dating for two months, was quite simply spectacular on her red carpet debut at the Venice film festival.
In a flowing teal gown, her hair and makeup natural, 'La Canalis' or 'Eli' as she's known locally caused a frenzy of excitement with the world's most desirable leading man by her side.
Their appearance has upped the glam factor considerably at the cine gathering, prompting the Italian press to hail them as the next Brad and Angelina.
The photogenic pair swept into the city from his Lake Como retreat earlier this week, arriving by water taxi in what seemed like a scene from one of the 48-year-old's movies.
It was the first truly public outing for the couple, who had until recently taken their meals at George's home, where the chef was instructed to fire up the wood-fire oven for homemade pizzas.
Meanwhile much of their free time has been spent lounging by the pool in the actor's secluded garden or on his boat.