The film has bagged six nods in total, including best actor for George, best director for Jason Reitman and best motion picture drama.
Close behind was musical Nine with five nominations, including acting nods for its three stars, Daniel Day-Lewis, Penélope Cruz and Marion Cotillard, and best motion picture comedy or musical.
Meryl Streep will be up against herself in the best actress in a comedy or musical category, winning nods for her roles in both Julie & Julia and It’s Complicated.
Homegrown talent Helen Mirren, Carey Mulligan and Colin Firth all got acting nods, as did Emily Blunt, who was nominated for her role in Sarah Ferguson-produced drama The Young Victoria.
The nominations were read out by pop star Justin Timberlake, Diane Kruger and Emily’s fiancé John Krasinski. And cheeky Justin could not resist a little joke as he announced Emily’s name.
"Ho, ho, ho! Somebody's going to have a good night tonight," he quipped to Office actor John.
There’s further British interest in the best song category where Sir Paul McCartney’s track I Want To Come Home will go head to head with U2’s Winter and the Leona Lewis-sung I Will See You from the movie Avatar.
In the TV section, high-school musical comedy series Glee led the way with five nominations.
Big Love, Dexter, Mad Men, True Blood and House fight it out for best TV drama, with Brit Hugh Laurie nominated for the fifth time for his role as Dr Gregory House in the best drama actor category.
Elsewhere, Brits Kenneth Branagh, Chiwetel Ejiofor and Jeremy Irons were all nominated in the best actor in a mini-series category, while acclaimed BBC Dickens adaptation Little Dorrit is up for best mini-series.
The ceremony, which will be hosted by Ricky Gervais, will take place on January 17 in Los Angeles.
For a full list of the nominees, click here