The move has caused some confusion amongst Corrie fans, as cast members posted pictures on Twitter after filming their "last scene".
"We're moving sets that's all people, relax," tweeted Brooke Vincent (Sophie Webster) after sharing a snapshot from the original set.
Alan Halsall, who plays Tyrone Dobbs, also had to explain the mix-up.
"After 16 yrs just filmed my last scene (at quay st site). fitting it was raining… 'Water way to end," he first tweeted next to a photograph of himself on the famous cobbles.
As his followers misread the message and reacted to the news, he added, "Not again people??? I put (at quay st site)!!! Corrie is moving from quay st site."
Hours later: "And still it continues…. zzzzz. Neither me or @jenniemcalpine are leaving corrie, corrie is moving sites!!"
Builders have spent two-and-a-half years recreating the famous terraced street on Salford Quays in Manchester.
The house are bigger and the road has been widened to allow two cars to pass, while lamp-posts have been moved back on the pavements and kerbs have been lowered to allow for easier filming.
Eagle-eyed fans might notice other subtle differences; for example, the Rovers Return now has two upstairs windows instead of just one.
"We've added an extra window here and there, which makes the buildings a little bit more realistic in terms of the huge clans that are living inside the houses," said executive producer Kieran Roberts.
"We've done hundreds and hundreds of things like that. We want to make sure this is the Coronation Street that our many millions of fans know and love.
"But we want to make sure this will equip us for a very bright future."