"Mercedes is leaving the village, she needs to give her high heels a rest – my feet are knackered," Jennifer told fans.
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Jennifer Metcalfe is leaving Hollyoaks after eight years playing Mercedes McQueen
It is not known if the actress is making a permanent departure from the Channel 4 soap, or is just taking a break – but it comes days after her on-screen sister revealed she is also leaving the show.
Gemma Merna will bow out on screen in an upcoming storyline after eight years playing Carmel McQueen.
She told the Daily Star Sunday, "I've had a great time being part of the show for eight years and I'm excited to push myself and explore new avenues.
Jennifer Metcalfe with her onscreen sister Gemma Merna (Carmel McQueen)
"I've got an exciting business launch for later in the year that I'm working on. I also have some great storylines before I go."
The McQueen family shake-up will also include the arrival of three new cousins. It has been confirmed that Myra's nieces Celine and Porsche will be appearing on the soap, joined at a later date by their teenage sister.
Nurse Celine, played by Sarah George, is described as having a huge heart but is "nobody's fool", while Porsche, played by Twinnie Lee Moore, has been billed as "racier than her four-wheeled namesake" Mercedes, but fiercely loyal with a "good moral compass".