Luckily the expectant star saw the funny side when Ellen told her she looked fat – so much so that she decided to share the quip with the audience as she presented Adam Sandler with an award.
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"Ellen DeGeneres just told me I was fat! But I'm not! It was really funny," said the 38-year-old star, who dressed her bump in a pretty white and pastel yellow Vionett dress.
Drew is expecting her second child with her husband Will Kopelman. The couple are already parents to baby Olive, who is one – and Drew recently confirmed they are set to welcome a second little girl.
She subtly shared the news in December while talking about her "future daughter" when accepting a beauty award in celebration of women.
A month previously, Drew shared her happy announcement, noting that: "Last time I never commented on it and people just stalked me the entire time,"
She added: "So yes, it's happening, it's true. I tried to keep it a secret for as long as possible.
"Will is just thrilled — we both are. We just wanted so badly for Olive to have a sibling. In some ways, it's really for her. So congratulations, Olive!"