Bruce Forsyth and Cilla Black joined Elaine Paige and Lord Lloyd-Webber in a standing ovation when the curtain came down on the show, a theatrical version of the American actress' 2003 hit film.
Before taking his seat at the London Palladium Bruce caught up with Whoopi outside the theatre. Afterwards he described the show - which is packed with disco, soul and gospel-influenced numbers by Oscar winning songwriter Alan Menken - as "absolutely tremendous".
Over 17 years have passed since the comic actress starred in the tale of Deloris Van Cartier, a singer who goes into hiding disguised as a nun after witnessing a murder. She reprised the role for the 1993 sequel, Sister Act 2: Back In The Habit.
Taking on the role originally filled by Whoopi is newcomer Patina Miller. Veteran small screen star Patricia Hancock plays Mother Superior – the part portrayed by Dame Maggie Smith in the movie.
While early reviews of the musical were mixed, the performances of its stars received a warm reception from theatre pundits. Bruce was also full of praise for the performers, saying Patricia was "magic" and describing Patina as "one of the most incredible performers I have ever seen".
He added: "She's got a dynamic personality-. Her singing, her moving, her acting are just wonderful."