The singer is currently on a humanitarian visit to Africa with their children, Rocco, nine, David, four, their adopted Malawian son, and Lourdes, her 13-year-old from a previous relationship and Mercy, a little girl she adopted on her own in June.
So with the kids away, the film director had plenty of time on his hands for night out on the town.
Guy spent the evening socialising with several attractive female friends. His party included gorgeous Jimmy Choo boss Tamara Mellon and equally glamorous society figure Diana Jenkins.
With his arm around both ladies and smiling broadly, the Lock, Stock and Two Smoking Barrels director - who recently spoke of the pain involved in the split - was the envy of every man in the room.
His renewed zest for life has made him one of the most sought after invitees at shindigs on both sides of the Atlantic.
Such is his cachet these days hostesses have been tripping over themselves to have the charismatic 40-year-old attending their dos.
And not surprisingly he topped one magazine poll's 'most invited' list for 2009.