That was certainly the case for Brad Pitt and Angelina Jolie, who couldn't help being attracted to each other as the bullets flew on steamy action film Mr and Mrs Smith.
Spain's own Brad and Angelina, Javier Bardem and Penelope Cruz also met on a shoot and are now expecting their second child.
CLICK ON PHOTOS FOR FULL GALLERY
Meanwhile, Jennifer Aniston finally found her match in Justin Theroux while making hippy flick Wanderlust and is soon to walk up the aisle a second time.
Other couples who flirted at the watercooler, so to speak, include Eva Mendes and Ryan Gosling, currently publicising Indie drama The Place Beyond The Pines, Claire Danes and Hugh Dancy and Ben Affleck and Jennifer Garner.
Take a look at this HELLO! Online round up of our favourite workplace romances.