The vessel, which was once capable of speeds of up to 17,000mph, finally arrived at its retirement home after a 12-mile trip which took three-days to complete.
On the back of a remote-controlled 160-wheel carrier and with more than 12 hours behind schedule, Endeavour reached the California Science Center past 1am on Sunday.
The spacecraft's final journey before beginning its years as a museum piece was cheered on by thousands of well-wishers, many of whom captured the moment on mobile phones and cameras.
More than 400 trees had to be cut to facilitate the route, in a journey that is estimated to have cost $10 million, to be paid for by the science centre and private donations.
During its road trip the shuttle stopped at the iconic Randy's Donuts building and at the Forum — former home of the Los Angeles Lakers basketball team — where it was greeted in the arena's parking lot by a throng of cheering spectators.