The fun-filled birthday party took place in London on Wednesday, as Harry welcomed guests to the Sentebale Summer Party at The Dorchester, Park Lane, London.
Also at the party with Harry was the charity's co-founder Prince Seeiso of Lesotho.
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Soul singer Joss Stone, who looked gorgeous in a royal blue dress, performed You Had Me. Beverley Knight, who is currently entertaining audiences in The Bodyguard musical, and magician Troy were also an integral part of the evening's entertainment.
Other guests included Westlife's Kian Egan and wife Jodi Albert, and Autumn and Peter Phillips.
This was Prince Harry's first public appearance since news broke of his split from Cressida Bonas.
The young prince seemed in high spirits as guests were treated to an impressive drinks reception and dinner, followed by awards to key individuals and organisations that have helped shape the charity over the years.
Prince Harry with Princess Mabereng and Prince Seesio at the Sentebale Summer Party
While Sentebale was officially set up in 2006, a statement released on the organisation's official website confirmed that "the evening is to mark 10 years since Prince Harry and Prince Seeiso made their commitment to help the vulnerable children of Lesotho." Bearing in mind that it was in 2004, while he was on his gap year, that Prince Harry visited Lesotho and made the pledge.
The pair, who have both lost their mothers, decided to set up Sentebale, which means 'forget me not' in Sesotho, in the hope of giving some of the most vulnerable children the chance of a happy, hopeful future.
Today, Sentebale works in partnership with local community-run organisations, NGOS, local government ministers and chiefs to provide healthcare and education to thousands of children who have been affected by the HIV/AIDS epidemic and extreme poverty.