"I've been in hiding because I'm afraid of people," the reality TV star says in the trailer for the upcoming series of Keeping Up With The Kardashians.
She adds, "I have major anxiety."
The 29-year-old, who separated from her basketball star husband Lamar earlier this year, breaks down in tears during the clip.
"I have to move on with my life and that means changing a lot," she says.
The couple parted after rumours of his drug addiction and cheating.
Despite their separation, it seems the famous family are still in regular contact with Lamar who calls Kardashian HQ and speaks to Khloé's sisters Kim Kardashian and Kourtney.
"I would do anything to be accepted back by you guys," he tells his sister-in-law Kim as Khloé looks on. "You guys are all I've got."
The next clip shows new mum Kim saying to someone – thought to be Khloé or Lamar, "We are a ride or die family. No matter what happens, we're always here to support you."
Khloé and Lamar aren't the only members of the family experiencing heartache.
Her mother Kris Jenner and stepfather Bruce Jenner have also recently separated. When the couple address the split their daughters become visibly upset.
"We're better as friends than we are the other way," explains Kris.
"Well then why are you still married?," asks 18-year-old model Kendall Jenner.
"Because our feelings are our feelings," Kris replies as she wipes the tears from her eyes.
Despite the upset, the family commit to staying strong and supporting one another with Kim leading the uplifting dialogue.
"We can't control other people, all we can control is ourselves," she says.
"Family united I agree," a more upbeat Khloé responds.
In the closing clip 'momager' Kris says, "Our family has never been stronger and nothing will tear us apart."