Two days after stepping out with just Antonio's name obscured from the tattoo, Melanie used make-up to completely cover the heart design on her right arm.
The 56-year-old, who split from Antonio after 18 years together, also moved her wedding ring to her middle finger.
Melanie Griffith covered her 'Antonio' tattoo with make-up
Melanie, who was joined at the Italian festival by Tiziana Rocca, Ben Stiller and his wife Christine Taylor.
New York-born Melanie filed for divorce from Antonio on 6 June, citing 'irreconcilable differences'.
Melanie Griffith covers up Antonio Banderas tattoo as she makes first post-split appearance
In a statement sent by their rep, the couple confirmed their split. "We have thoughtfully and consensually decided to finalise our almost twenty years marriage in a loving and friendly manner, honouring and respecting each other, our family and friends and the beautiful time we have spent together."
A source close to the actress said that the couple, who have a 17-year-old daughter Stella together - had been having marital problems for some time.
"The split is not something new and out of the blue - they have had issues for years," the insider told People. "The fights and separations got to be too much."