According to People, 32-year-old Misty, who was nominated for an Independent Spirit Award for her role in 2008 film Frozen River, has been missing for six days and was last seen on Sunday leaving her apartment in Auburn, Washington.
Misty in November 2013
Police were called to her home on Sunday following a call made by the star, but by the time they arrived she had already left prompting her father Charles to list her as a missing person.
"She has not been in contact with her family or friends since her disappearance," said Charles in a statement. "We are doing everything within our means to bring our daughter home safe."
Left to right: Misty, Juliette Lewis, Julianne Nicholson, Dermot Mulroney and Julia Roberts
Misty's family have been posting updates about their efforts to find her on her Facebook page and have been trying to coordinate a search party.
Until recently Misty had been working on a new film called Cake, which also stars Jennifer Aniston, Anna Kendrick and Sam Worthington.