On Wednesday 7 May Harry and the charity's co-founder Prince Seeiso of Lesotho will welcome guests to the Sentebale Summer Party at The Dorchester, Park Lane, London.
The evening will feature performances by You Had Me singer Joss Stone, The Bodyguard musical's leading woman Beverley Knight and entertainment from magician Troy.
Singer Joss has long been involved with Sentebale and spent the month of April visiting Lesotho to work with visually impaired children and help raise awareness for their cause.
Prince Harry goes back to baking for his charity Sentebale
Guests at the party will also be treated to a VIP drinks reception and dinner, followed by recognition awards to celebrate key individuals and organisations that have shaped the charity into what it is today.
Joss Stone has been seeing the work Senteable do in Lesotho
While Sentebale was set up in 2006, a statement released on the organisation's official website confirmed that "the evening is to mark 10 years since the Prince Harry and Prince Seeiso made their commitment to helping the vulnerable children of Lesotho" as it was in 2004, while he was on his gap year, that Prince Harry visited Lesotho.
Harry makes a surprise visit to Chelsea Flower Show to see his charity Sentebale's garden
Harry was shown around the country by Prince Seeiso and was overwhelmed by the poverty and hardship faced by many children.
Harry after taking part in a polo match for Sentebale
The pair, who have both lost their mothers, decided to set up Sentebale, which means 'forget me not' in Sesotho, in the hope of giving some of the most vulnerable children the chance of a happy, hopeful future.
Prince Harry to follow in Princess Diana's footsteps with charity visit
Today, Sentebale works in partnership with local community-run organisations, NGOS, local government ministers and chiefs to provide healthcare and education to thousands of children who have been affected by the HIV/AIDS epidemic and extreme poverty.