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"I wanted to take time to add my name to this video by Future View called Ebola is Real. It's an educational piece that will keep you guys safe on how to treat and prevent the spread of Ebola."
He adds: "Health care workers down in West Africa have been doing a tremendous job and long may that continue. I want to congratulate them on the tackling and prevention of the disease - it's a horrible disease and working in very difficult circumstances.
"So please listen to the health care workers. They know what they're talking about."
He finishes: "I just want to say keep safe - the world is thinking of you and be safe."
The video comes a few weeks after the Queen made a donation to the Disasters Emergency Committee which is trying to raise funds to send support to those in the affected countries.
The 32-year-old Prince's message also comes a day after the release of Band Aid 30's Do They Know It's Christmas, which this year will raise money to help combat the crisis.