Amid ongoing reports that the couple's six-year union is in crisis, Nick, 33, has confirmed that there is "trouble in paradise".
He told the Insider that he and Mariah have been "living in separate houses for a few months", but denied that infidelity was the cause of the issue.
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Nick Cannon has confirmed that he and wife Mariah Carey are living apart
Nick added that the couple's three-year-old twins, Monroe and Moroccan, were his "main focus".
Mariah Carey and her 'loverboy' Nick Cannon – a whirlwind romance
A publicist for Mariah, 44, meanwhile, said, "I am not commenting on Mariah's personal life, but Mariah is focusing on her children and her upcoming tour."
In recent months, Nick and Mariah have found themselves at the centre of the latest celebrity split rumours, with one outlet claiming their divorce is a "done deal".
Mariah Carey and Nick Cannon with their three-year-old twins Monroe and Moroccan
With millions of dollars at stake, their lawyers are said to have been negotiating property settlements and custody arrangements for the twins for months.
The couple's last social media posting together was in June, when Mariah shared a family photo in honour of Father's Day.
It is thought that the pair separated in May, but Nick told Parade at the time there was no truth to reports they were divorcing.
The couple married in April 2008 after a whirlwind six week romance
"You kind of have to ignore it because every week it's something different," the TV star said. "And if you paid attention to it, it actually probably would start really affecting you…
"There's no merit or truth to it. It's kind of humorous, really. It couldn't be further off from the truth..."
Mariah and Nick married in April 2008 after a whirlwind six week romance, and every year since, they have renewed their wedding vows.
Mariah Carey and Nick Cannon renewed their vows in Paris in 2012
While in the past they have opted for elaborate ceremonies – at Disneyland in 2013, and in Paris in 2012 – Nick told Parade that this year they had chosen something that was "low key".
"I mean, the year before, we kind of went over the top with Disneyland, so we kind of wanted to reel it in this year so everybody doesn't think that we try to do that every single year," he said.